As you gaze upon these phrases, expensive reader, a horde of alien marauders are ransacking all corners of the globe, chewing via the newest pharmaceutical defenses and abandoning a ugly path of lifeless and weakened victims. In accordance with a current report by the World Well being Group (WHO), ferocious tribes of micro organism, parasites, viruses and fungi are on the rampage, and a few are proving just about invincible to the so-called “final resort” antibiotics.

WHO has recognized the proliferation of antibiotic-resistant “superbugs” as one of many main looming heath crises of the 21st century. These artful, elusive shape-shifters will not be solely able to surviving an onslaught of antibiotics, however they regularly reinvent themselves by genetic mutation, horizontal gene switch and pure choice, creating new techniques towards even probably the most highly effective medicine and spawning malignant offspring that wreak havoc with devastating vitality. They even share their genetic materials with different pernicious bugs.

The foremost offenders on this perilous battle will not be simply the superbugs themselves however the rampant overuse of antibiotics. It’s estimated that 30% of all prescribed antibiotics are pointless, a testomony to our tradition’s want for quick-fix options to our well being woes. (This doesn’t bear in mind the truth that the majority of all antibiotics utilized in the USA are given to livestock, an entire different ball of worms.) The follow of scribbling a script for each little sniffle has helped create a vicious circle of weakened immune techniques, ravaged intestine microbiomes, and the escalating unfold of harmful illnesses by folks, animals, and agricultural crops.

When the U.S. Heart for Illness Management (CDC) throws phrases round like “nightmare” and “sound the alarm,” it’s time to take discover. “With out pressing motion,” the CDC warns, “many fashionable medicines may change into out of date, turning even frequent infections into lethal threats.” The CDC’s current antibiotic resistance initiative features a key purpose: to chop inappropriate prescribing practices by 50% in medical doctors’ workplace and 20% in hospitals. And whereas this protocol has helped to rein in some infectious foes, others are on a daunting upswing.

MRSA kills

Probably the most treacherous malefactors on the prowl is Methicillin-resistant Staphylococcus Aureus, or MRSA. This extremely contagious bacterial an infection is often related to individuals who have compromised immune techniques, like hospital sufferers and the aged. Over the previous decade, an much more menacing pressure of community-associated MRSA (CAMRSA) has muscled its approach into more healthy populations, popping up like a malevolent jack-in-the-box in locations and conditions the place individuals are packed tight— contact sports activities groups; gyms and locker rooms; colleges and daycare services; prisons, homeless shelters, and army barracks. CAMRSA is even turning up in spas, resorts, cruise ships, and nail salons.

One out of each hundred hospitalizations in the USA is because of a MRSA an infection, and a couple of quarter of these change into significantly invasive, killing 20,000 folks annually. A current report by the CDC signifies that hospitals have made progress in lowering charges of MRSA, however CAMRSA charges haven’t declined and now comprise 80% of all MRSA infections. The illness has change into so prevalent that October 2 is depressingly referred to as “World MRSA Day.”

In accordance with researchers, CAMRSA is a crafty bacterial pressure with a bunch of organic methods up its sleeve. It has the distinctive capacity to cover and disguise itself towards neutrophils. Neutrophils are generally generally known as white blood cells, particularly those tasked with preventing off these Machiavellian villains. Much more sinister, CAMRSA secretes a nasty little peptide that wreaks havoc in two methods: it helps construct a biofilm, a slimy construction that permits the bug to stay to its host and unfold quickly, and even creepier, it commits a heinous bio-crime referred to as lysis, infiltrating neutrophils and really inflicting them to blow up, thereby shattering the physique’s immune protection mechanism.

Left untreated, CAMRSA can result in sepsis, endocarditis, pneumonia and necrotizing fasciitis (necrosis comes from the Greek nekrōsis, “to make lifeless”). All of those problems are doubtlessly deadly, and the beta-lactam antibiotics usually prescribed for staph (single-molecule medicine similar to penicillin, cephalosporins, monobactams, and carbapenems) are proving to be not efficient. Even Vancomycin, an “antibiotic of final resort,” is shedding the combat towards CAMRSA. To complicate issues much more, using antibiotics – and the ensuing disruption of the physique’s wholesome intestine micro organism – is more and more proven to contribute to future well being issues.

Indignant purple pustules

The primary time I heard of MRSA was within the late 1990’s. An expensive childhood pal contracted the an infection, and it had change into dangerously systemic. After medical doctors tried each obtainable therapy – together with a strong course of IV antibiotics that turned my pal beet-red, coated him in hives, ravaged his kidneys, and made him so dizzy and nauseous he couldn’t hold meals down –he died from related problems.

What does it imply to guard ourselves in a world crawling with MRSA and different superbugs? Past the plain like washing our fingers, we’d like efficient choices to combat infections that don’t rely solely on antibiotics. Scientists are researching new remedies that focus on bacterial unhealthy guys in novel methods, however this can be a laborious and time-consuming course of. Within the meantime, there are different weapons we will wield to guard ourselves from these insidious infiltrators – as I discovered the exhausting approach after I myself was contaminated by MRSA just a few years in the past.


I’d spent a pleasurable California weekend within the close by resort city of Calistoga, soaking in healthful, mineral-rich waters. I returned house absolutely rejuvenated and freed from stress. Or so I assumed. Two days later, my physique was bitmapped in boils and I used to be shedding my thoughts. A platoon of indignant purple pustules had taken up residence throughout my again. For a gentle pores and skin situation, I’d usually attain for a plant-based therapy, however this bacterial ambush was so sudden and aggressive – and so disgusting – I wasn’t going to fiddle.

I went straight to my GP, who identified a staph an infection and prescribed an antibacterial pores and skin cleanser and a topical antibiotic ointment. At first, I used to be considerably relieved that this therapy wouldn’t contain carpet-bombing my pleasant neighborhood of intestine micro organism, given the significance of an up-to-snuff microbiome in so many features of our well being. However after every week of washing my occupied territory as directed and making use of the ointment twice every day, my bêtes noires present no signal of retreating. Like Napolean’s military, they had been conquering new territory and morphing into one thing much more répugnant.

I felt contaminated, radioactive. I averted folks and slunk round like Quasimodo, lurking within the shadows. And I fearful. Lined by crusty carbuncles, I used to be turning into a modern-day model of Baba Yaga, the boil-ridden witch of Russian folklore who lived deep within the forest in a hut that stood on a pair of hen legs. Alas, I had her pus-filled boils, however none of her magic powers.

Hashish & antibiotic resistance

Alarmed at my lack of enchancment, my physician prescribed a course of oral antibiotics. I knew in regards to the affiliation of the microbiome with psychological well being, and now pictured myself rotting away in an asylum, my thoughts gone to mush in any case of my intestine micro organism had been worn out. There needed to be a greater approach. More and more determined, I began trying into no matter analysis was obtainable about cannabis and antibiotic-resistant micro organism.

Sadly, attributable to marijuana prohibition, there’s not a lot on the market on this topic. (Thanks once more, Feds, for the dearth of science.) I discovered just a few related articles in peer-reviewed journals, which underscored the complicated and nuanced impact cannabis has on immune operate. In a current evaluation in NeuroImmunoModulation, a crew of Mexican scientists reported that cannabinoids  demonstrated a statistically vital antibiotic impact on some infectious illnesses, and really impaired the physique’s immune system for others.

Cannabidiol (CBD) and cannabigerol (CBG) present potent exercise agains a wide range of MRSA strains.

The excellent news is that a number of plant cannabinoids have been proven to wreak havoc towards Staphylococcus aureus – the very bug I used to be preventing. A 2008 research within the Journal of Pure Merchandise, revealed by the American Chemical Society, discovered that cannabidiol ( CBD) and cannabigerol (CBG), two nonintoxicating cannabinoids, “confirmed potent exercise towards a wide range of MRSA strains.” Three different plant cannabinoids – tetrahydrocannabinol (THC), cannabinol (CBN) and cannabichromene (CBC) – additionally confirmed encouraging ends in preclinical analysis. How the cannabinoids work just isn’t absolutely understood, nevertheless it seems to be attributable to pure antimicrobial protection mechanisms.

The journal concluded: “Given the supply of C. sativa strains producing excessive concentrations of nonpsychotropic cannabinoids, this plant represents an fascinating supply of antibacterial brokers to handle the issue of multidrug resistance in MRSA and different pathogenic micro organism. This situation has huge medical implications, since MRSA is spreading all through the world and, in the USA, at present accounts for extra deaths annually than AIDS. Though using cannabinoids as systemic antibacterial brokers awaits rigorous medical trials … their topical utility to scale back pores and skin colonization by MRSA appears promising.”

CBD and mānuka honey to the rescue

I additionally heard in regards to the potent antibiotic properties of mānuka honey, and I considered combining it with a CBD-rich cannabis extract. Whereas honey has been recognized since historic occasions for its antibiotic and wound-healing properties, mānuka is one thing particular. Made by bees from the nectar of Leptospermum scoparium (extra generally generally known as tea tree, a plant indigenous to New Zealand and Australia), mānuka honey has distinctive bacteria-busting skills that scientists have solely lately begun to analyze.



A 2016 article revealed in Frontiers in Microbiology discusses how mānuka honey disrupts invading micro organism’s capacity to supply biofilms. In one other research, mānuka was proven to forestall bacterial subdivision, and it seems to evade bacterial resistance. Not solely is mānuka honey efficient by itself, nevertheless it additionally works synergistically with different antibiotics, rising their effectiveness.

So, I took issues into my very own fingers and made my very own bacteria-killing juice. I decarboxylated the dried flowers of a CBD-rich cannabis pressure referred to as Blue Jay Approach, which was lab-tested to point out a 2-to-1 ratio of CBD-to-THC (14% CBD and seven% THC). I infused some olive oil utilizing the outdated hippie Crockpot methodology. After straining out the plant materials, I added some beeswax for its thickening properties. And when the infusion was largely cool, I combined in a beneficiant quantity of New Zealand mānuka honey with 20+ bioactivity.

I utilized this salve to my pores and skin an infection twice per day. It was a bit of sticky, however that was the worst of it. Inside 24 hours, it began working! Just like the water-splashed Depraved Witch of the West within the Wizard of Oz, the lesions started shrinking and drying up. Over the subsequent few days, I gleefully watched because the pores and skin on my again grew to become a killing subject the place all these little, white-blood-cell-exploding staph-holes had been obliterated ceaselessly. Inside every week, the an infection had resolved utterly, leaving my intestine flora intact.

In contrast to my expertise with pharmaceutical antibiotics, whole-plant CBD-rich cannabis mixed with mānuka honey didn’t trigger any antagonistic negative effects. Nor did it set off a backlash of antibacterial resistance, which is threatening the very foundations of Western medication. We’ve change into more and more dependent upon medical conveniences, fast fixes and silver bullets, whereas usually ignoring their broader penalties. In our impatience to get on with the enterprise of life, we don’t at all times take note of the subtler conversations our our bodies keep it up, day and evening, in our microbiomes and past. Possibly it’s time to pay attention.

Melinda Misuraca is a Venture CBD contributing author with a previous life as an old-school cannabis farmer specializing in CBD-rich cultivars. Her articles have appeared in Excessive Occasions, Alternet, and a number of other different publications.


Almasaudi SB, Al-Nahari AAM, Abd El-Ghany ESM, Barbour E, Al Muhayawi SM, Al-Jaouni S, Azhar E, Qari M, Qari YA, Harakeh S. Antimicrobial impact of various kinds of honey on Staphylococcus aureus. Saudi J Biol Sci. 2017 Sep;24(6):1255-1261. doi: 10.1016/j.sjbs.2016.08.007. Epub 2016 Aug 30. PubMed PMID: 28855819; PubMed Central PMCID: PMC5562472.

Alvarez-Suarez JM, Gasparrini M, Forbes-Hernández TY, Mazzoni L, Giampieri F. The Composition and Organic Exercise of Honey: A Give attention to Manuka Honey. Meals. 2014 Jul 21;3(3):420-432. doi: 10.3390/meals3030420. Evaluation. PubMed PMID: 28234328; PubMed Central PMCID: PMC5302252.

Appendino G, Gibbons S, Giana A, Pagani A, Grassi G, Stavri M, Smith E, Rahman MM. Antibacterial cannabinoids from Hashish sativa: a structure-activity research. J Nat Prod. 2008 Aug;71(8):1427-30. doi: 10.1021/np8002673. Epub 2008 Aug 6. PubMed PMID: 18681481.

Feldman M, Smoum R, Mechoulam R, Steinberg D. Antimicrobial potential of endocannabinoid and endocannabinoid-like compounds towards methicillin-resistant Staphylococcus aureus. Sci Rep. 2018 Dec 6;8(1):17696. doi: 10.1038/s41598-018-35793-7. PubMed PMID: 30523307; PubMed Central PMCID: PMC6283871.

Rigby KM, DeLeo FR. Neutrophils in innate host protection towards Staphylococcus aureus infections. Semin Immunopathol. 2012 Mar;34(2):237-59. doi: 10.1007/s00281-011-0295-3. Epub 2011 Nov 12. Evaluation. PubMed PMID: 22080185; PubMed Central PMCID: PMC3271231.

Ventola CL. The antibiotic resistance disaster: half 1: causes and threats. P T. 2015 Apr;40(4):277-83. PubMed PMID: 25859123; PubMed Central PMCID: PMC4378521.